hrp0089p2-p066 | Diabetes & Insulin P2 | ESPE2018

Prothrombin Gene 20210A Mutation Heterozygosity and MTHFR Gene C677T Mutation Homozygosity Detected in a Male Toddler Experiencing Femoral Venous Thrombosis During Diabetic Ketoacidosis

Kleisarchaki Angeliki N , Giza Styliani , Nikolaidou Olga , Mouzaki Konstantina , Kotanidou Eleni P , Litou Eleni , Rengina Tsinopoulou Vasiliki , Papadakis Emmanouil , Galli-Tsinopoulou Assimina

Introduction: Diabetic ketoacidosis (DKA) as an inflammatory state combined with the disruption of the normal coagulation cascade can lead patients to an increased risk of thrombosis. Especially, patients that are genetically susceptible to thrombosis could develop deep venous thrombosis (DVT) due to inflammation, dehydration, and hyperviscosity secondarily to DKA. It is noteworthy that children with DKA who underwent central venous catheter placement could develop DVT, especi...